NDTi

recent research on anti-biotic, minocycline and mental illness

2013-05-01T14:02:24+00:00

Please se reports of recent research of minocycline on mental illness including schizophrenia/autism.

The Independent (newspaper)

article by Jeremy Laurance in dated 02/03/12

Scientists shocked to find antibiotics alleviate symptoms of schizophrenia

Chance discovery of link between acne drug and psychosis may unlock secrets of mental illness

Also

Psychiatry Weekly: Use of The Antibiotic Minocycline To Treat Catatonic Schizophrenia

Psychiatry weekly
Jan 15th 2007
Use of The Antibiotic Minocycline To Treat Catatonic Schizophrenia
Dr.David L Ginsberg
[U]Part of the article by Dr Ginsberg is printed below

January 15, 2007
David L. Ginsberg, MD

Director of Outpatient Services, Tisch Hospital’s Department of Psychiatry, New York University Medical Center

Minocycline is a semisynthetic second-generation tetracycline which exerts anti-inflammatory effects that are separate and distinct from its anti-microbial action (MacDonald et al. 1973). One of the more brain-penetrable tetracyclines, minocycline has been shown to have neuroprotective effects in models of ischemic injury (Yrianheikki et al. 1999) and the 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine model of Parkinson’s disease (Du et al. 2001). While direct neuroprotective effects have been observed some of its actions result from indirect effects in inhibiting glial (astrocytic;/microglial) caspase 1 and iNOS activity (Amin et al. 1996; Yong et al. 2004). Recent reports indicate that minocycline delays mortality or disease progression in mouse models of Huntington’s disease (Chen et al. 2000; Berger 2000) and amyotrophic lateral sclerosis (Zhang et al. 2003). There is also a case report in humans of possible antidepressant effects of minocycline, which has been attributed mechanistically to the inhibition of noradrenaline-sensitive adenylate cyclase (Levine et al. 1996). Now comes a report of 2 cases of acute schizophrenia with predominant catatonic symptoms that responded well to minocycline (Miyaoka et al. 2007).

In the first case, a 23 year-old man, college graduate employed by a company, with no prior neurologic or psychiatric history developed insomnia and anxiety. Further, he became agitated and talked incoherently with persecutory delusions and paranoid ideation. He was admitted to a Japanese hospital. Examination of his mental state revealed auditory hallucinations, persecutory delusions, psychomotor excitement, catatonic stupor, and deterioration in the level of social functioning. Physical and neurologic examinations were normal. Complete work-up including laboratory testing of serum and urine, electroencephalography (EEG), computed tomography (CT) and magnetic resonance imaging (MRI) of the brain were all normal. Diagnosed with catatonic schizophrenia, the patient was started on haloperidol, titrated to 20 mg/day. One week later, his psychomotor excitement, auditory hallucinations, persecutory delusions, and catatonic stupor persisted. In addition, his symptoms were complicated by severe pneumonia. Serum creatine kinase and renal parameters were normal. Minocycline 150 mg/day was initiated to treat the pneumonia. Two weeks later, the pneumonia and psychiatric symptoms resolved. Minocycline was discontinued for one week; subsequently the psychiatric symptoms significantly worsened. As a result, minocycline 150 mg bid was resumed. Within 3 days, a noticeable clinical improvement was observed. The patient continued minocycline 150 mg/day and haloperidol 20 mg/day. Twenty-four days later, the patient became practically symptom-free. On the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), his score declined from approximately 38 to 12. His haloperidol was reduced to 10 mg/day, then over the next 2 and ½ weeks to 2 mg/day. Minocycline was maintained at 150 mg/day. At last follow-up two years later, the patient continued to do well with no worsening of psychiatric symptoms.

The second case involved a 61 year-old man with schizophrenia since the age of 20 and five prior psychiatric hospitalizations. During his last admission, he deteriorated and became autistic, and so remained in the hospital for 4 years. He was treated with haloperidol 10 mg/day and risperidone 2 mg/day. Routine laboratory testing including blood, urine, and feces were within normal limits. Electroencephalography (EEG), computed tomography (CT), and magnetic resonance imaging (MRI) of the brain were all negative. One year prior, the patient had developed psychomotor excitement, catatonic stupor, and negativism. In addition, a large decubitus formed on his left hip. Minocycline 150 mg/day was initiated. Haloperidol and risperidone were continued at their previous doses. Two weeks later, the decubitus healed. Minocycline was discontinued for one week. This was followed by a significant worsening of his psychiatric symptoms; his PANSS score which had declined from 25 to 10, now increased to 40. As a result, minocycline was resumed at a dose of 150 mg bid. Within 3 days, noticeable clinical improvement was observed (PANSS = 10). Minocycline was reduced back to 150 mg/day while his antipsychotics were continued at their previous dosages. After another 13 days, the patient became practically symptom-free. Haloperidol was descreased to 3 mg/day while risperidone was discontinued. Of note, throughout his course, the patient did not have fever or receives benzodiazepines. At last follow-up one year later, the patient continued to do well with no worsening of psychiatric symptoms.

This appears to be the first published report on the successful use of minocycline to treat psychosis and catatonia. While antipsychotics were also administered to these patients, the temporal sequence of events described is consistent with at least some of the benefit deriving from minocycline. Furthermore, benzodiazepines and/or electroconvulsive therapy (ECT) usually are needed for effec

adapting the inclusion web

2012-10-24T13:07:26+00:00

Hi,

I’ve introduced the inclusion web to a local support provider for people with learning disabilities. We are working on a way of helping people embed photos/video of their places and people so that those who cannot read can have a web they understand on a computer/dvd. Once we have the glitches worked out I’m happy to post a version here if that is possible or welcome?

Margaret Cushen

Mental Health PbR Discussion Group

2012-01-12T11:45:10+00:00

With the NHS developing mental health ‘care clusters’ in response to the shift to payment by results, and the Government also demanding the implementation of personalisation (which is a clear priority for local government), there is a real danger that these two policies are not ‘talking to one another’ and the mental health PbR systems will be developed in a way that runs counter to the aspirations of PbR. NDTi have produced a discussion document to help promote debate about how to avoid this happening and we would welcome your thoughts and contributions.

You can see the document at www.ndti.org.uk/who-were-concerned-with/mental-health/payment-by-results-and-personalisation-in-mental-health-services/ and it is also attached to this post.

We have already been discussing this issue with a number of interested parties, including SCIE, Think Local Act Personal and the SHAs. After allowing a period of time for people to comment, we will consider with those colleagues and others, how best to take this agenda forward.

To post a comment on this forum, please do the following:
1. Please press ‘Login’ at the top of your screen (It says: ‘Welcome Guest, please Login’)
2. Type in the Login details – Username: ndtiguest Password: payment
3. Click on the discussion thread entitled ‘Payment by results and personalisation in mental health services’
4. Click on ‘Mental Health PbR Discussion
5. Group’ Click on ‘Post Reply’ to post a comment

Kind regards
Kate Linsky

NDTi
Head of Development - Mental Health

Letter to the Prime Minister

2011-06-27T12:40:39+00:00

After the Panorama programme that exposed the abuse of people with learning disabilities at Winterbourne View, 86 people and organisations wrote to the Prime Minister saying what we think needs to be done so that these things do not happen again.

You can see the original letter (including an easy read version) on this website:
www.ndti.org.uk/news/national-news/a-national-response-to-the-abuse-of-people-with-learning-disabilities1/

Since then, a lot of other people have said they would like to sign the letter as well. This is your way to do that. Please click on ‘Post Reply’ below and add your name and how you want to be described (it could be a job title or something like ‘person with a learning disability’ or ‘parent’) and click on ‘Submit’. If you are signing on behalf of an organisation, please write “on behalf of”.

Please do not write anything else on this on your reply such as comments on what you think about the issue. This will make it more difficult to add names to the letter. We are creating a Facebook page for people who want to talk about the issues in more detail.

We will then copy all the names onto the ‘master copy’ of the letter, which you can see with all the latest names to be added by going to the CB-NSG website at:
www.thecbf.org.uk/pdf/Anationalresponsetotheabuseofpeoplewithlearningdisabilities.pdf

We will also put details of any replies we get on that website.

Thank you.

Web Calculation Master Workbook - spreadsheet to download

2011-04-14T14:24:29+00:00

Web Calculation Master Workbook - this can be used to enter scores from using the Inclusion Web and analyse results for a number of people who have used the Inclusion Web. Full instructions are provided within the spreadsheet.

South Wales pilot

2011-04-07T09:56:29+00:00

Hi Peter
I met with the staff in South wales on Wednedsday to ‘kick start’ thepilot which we hope will involve around 16 people. Thje Manager was impressed, and very enthusiastic about the Ws potential for improving quality of life and stimulating thought about engaging with the community. I’ll keep you posted,

Adrian

Inclusion Web

2011-01-21T13:43:32+00:00

After reciving the new version of the inclusion web, which looks great, we have begun a pilot scheme with ten service users, who will be moving to new properties in the next twelve months.
The inclusion web has also been disscused in a series of workshops and we have had good feed back from staff

Have you been using the old Inclusion Web scoring form?

2011-01-19T15:01:21+00:00

If so, you can use the spreadsheet below to convert your results into the new format needed for the Web Calculation Master Workbook.

Supporting documentation for the Inclusion Web Resource Packs available to download

2011-01-19T14:57:31+00:00

The Inclusion Web Leaflet - a printable copy of the leaflet provided in the Resource Pack. Please note that we recommend printing page 2 in A3 format. More copies of the pre-printed leaflet can be purchased through our Bath office - see the order form below.

Consent Form - a printable version of the form provided in Section 4 of the Resource Pack.

Order form - you can now order further copies of the pre-printed leaflet - £25 for 50 copies including P&P.

Welcome to the NDTi Forums

2011-01-19T11:22:35+00:00

Welcome to the NDTi Forum.

We hope that these forums will be helpful, informative and promote discussions between various groups of people.

If you have any questions about using the forums, please do not hesitate to contact me.

Kind regards
Sarah
NDTi Website Manager

e: sarah dot morris at ndti dot org dot uk
t: 01202 471423